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A. Gambardella

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Open access Sep 2026

Cenobamate Improves Emotional Dysregulation, Impulsivity, and Apathy in Drug-Resistant Focal Epilepsy: A Longitudinal Neuropsychological Study.

INTRODUCTION Although effects on cognitive function have been reported during cenobamate (CNB) treatment, far less is known about how it may affect neuropsychological domains such as apathy, emotion dysregulation, and impulsivity. This prospective longitudinal study aims to assess psychopathological and cognitive chang...

I. Sammarra, Adriana Saraceno, Iolanda Martino et al. · 0 citations
Open access Aug 2026

Impact of Age on the Diagnostic Yield of Routine EEG in People With Childhood or Juvenile Absence Epilepsy: A Cross-Sectional Study.

Age significantly reduces the diagnostic yield of rEEG in CAE and JAE, regardless of ASM treatment, and Youden's exploratory analysis identified ≥ 14 years as the optimal threshold for predicting a rEEG negative.

F. Fortunato, A. Giugno, M. Sturniolo et al. · 0 citations
Open access Aug 2026

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy.

No meaningful association between PRS and age at onset, history of febrile seizures, pre-/perinatal complications, epilepsy syndromes, seizure types, co-occurrence of functional/dissociative seizures, psychiatric comorbidities, electroencephalographic/magnetic resonance imaging findings, or drug response could be demon...

Sophie von Brauchitsch, Nils Hartung, R. Karge et al. · 0 citations
Jul 2026

Drug-treatment changes, depression, and quality of life in adults with drug-resistant focal epilepsy.

Seizure freedom can improve all domains of QoL, but mainly Seizure worry, although this can be negatively affected by depressed mood, and improvement in the domain of Social functioning requires a period of sustained seizure freedom longer than 6 months to improve, and it is negatively influenced by persistent depresse...

Marco Mula, S. Borghs, Bruno Ferrò et al. · 0 citations

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