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Open access Aug 2026

Capsid stabilization reprograms the nuclear fate of the HIV genome

Capsid stabilization, induced by low-nanomolar concentrations of Lenacapavir (LEN)—a first-in-class capsid inhibitor—impedes HIV-1 replication in macrophages without disrupting reverse transcription or nuclear import. In LEN-treated cells, ultrastructural analyses reveal preserved conical capsids persisting within nucl...

Thierry Mourer, M. Harastani, Celine Cuche et al. · 0 citations
Open access Sep 2026

Rapid repurposing of microvillar content drives a flagellate-to-amoeboid switch in the closest relative of animals

Animal cells extensively remodel their cytoskeleton during differentiation and can notably switch between two major motility modes: flagellum-based swimming and actin-based crawling. We previously showed that choanoflagellates, the closest living relatives of animals and classically viewed as obligate flagellated swimm...

Maite Freire-Delgado, Diede de Haan, Stéphane Tachon et al. · 0 citations

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