Author

A. George

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Open access Aug 2026

Structure-based scaffold hopping reveals strategies to overcome oncogenic KIT and PDGFRA mutation-driven drug-resistance in GIST

A structure-based scaffold-hopping strategy to design kinase inhibitors with selectivity for mutant KIT/PDGFRA and the PDGFRA-G680R structure shows the molecular basis for targeting solvent-front mutations across oncogenic kinases.

T. Schulz, M. Beerbaum, A. Scrima et al. · Nature Communications · 0 citations