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This complete genome of a songbird serves as a public reference and illuminates avian genome architecture and function and suggests that birds possess a kinetochore-associated CENP system similar to that of mammals.
Findings identify microglial senescence as a core consequence of telomere shortening and reveal sDLK1 as a microglia-derived senescence ligand that drives oligodendrocyte and neuronal dysfunction in aging.
It is demonstrated that pathology-defined cell states provide a more reproducible framework for studying ALS transcriptomic alterations than conventional case-control comparisons and an interactive browser is provided to facilitate exploration and comparison of ALS snRNA-seq datasets.
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