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Open access Aug 2026

A biobank-scale method for learning modulators of gene-environment interaction underlying human complex traits from multiple environmental exposures.

Efficient multi-eNvironmental Gene-environment Interaction iNference Estimator (ENGINE), a supervised variance-component framework that learns an embedding that combines multiple environmental exposures while jointly estimating additive, G×E, and heteroskedastic noise components, making polygenic G×E analysis tractable...

Zheng-Tong Liu, Arush Ramteke, Aakarsh Anand et al. · 0 citations

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