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Author

A. Grumach

2 papers indexed here

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2025

The broad spectrum of immune dysregulation: clinical cases

INTRODUCTION: Inborn errors of immunity are classified according to the many possible genetic defects, and 25% manifest as immune dysregulation. CTLA-4 (cytotoxic T-lymphocyte antigen 4) haploinsufficiency has been associated with variable clinical presentations, ranging from asymptomatic carriers (30%) to patients wit...

João Pedro Araujo da Costa Aires, Paula Christina Cavallini de Melo Maricondi, A. Grumach et al. · 0 citations
Open access Oct 2026

Oral deucrictibant for on-demand treatment of hereditary angioedema attacks: a phase 3, multicentre, randomised, double-blind, placebo-controlled crossover trial.

The use of deucrictibant as potentially the first orally administered bradykinin B2 receptor antagonist for the treatment of attacks of bradykinin-mediated angioedema, including hereditary angioedema, is supported and may address an unmet need for options that are effective and well tolerated, with convenient administr...

M. Riedl, P. Li, A. Adatia et al. · 1 citation

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