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Review Open access Sep 2026

Molecular Glue Degraders in Early Development for Cancer Therapy.

Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein-protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are not typically recognized by a specific E...

E. Ozdemir, H. Jang, Ozlem Keskin et al. · 0 citations

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