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A. H. Jonsson

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Open access Sep 2026

Extraintestinal Reprogramming of Colon-Derived CD4+ Intraepithelial Lymphocytes Reveals a Mechanism Underlying the Gut-Joint Axis.

OBJECTIVE The gut-joint axis is a central paradigm in spondyloarthritis, yet the cellular mechanisms linking intestinal and joint immunity remain poorly understood. One potential link is TCRαβ+ CD4+ intraepithelial lymphocytes in the colon (cIELs) that can traffic to extraintestinal tissues, including the joint. Within...

S. M. Danielson, Connor Eck, Su-Cai Liu et al. · 0 citations

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