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Review Open access Oct 2026

Chemical reactions for the ligand-directed modification of native proteins

Selective modifications of native proteins provide powerful opportunities to study and manipulate biological systems, yet achieving site-selective functionalization remains challenging due to the surfeit of competing amino acids, often addressed by genetic engineering of target proteins. Ligand-directed protein modific...

A. Haim, Cassandra J. Henderson, M. Akdeniz et al. · 0 citations

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