Author

A. Harduin-lepers

2 papers indexed here

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Open access Oct 2026

An Integrated Workflow for Real-Time Chemoenzymatic CMP-Sialic Acid Preparation and a Bioorthogonal Microplate Sialyltransferase Assay (MPSA)

Sialylation at the terminal ends of cell-surface glycoproteins and glycolipids plays a pivotal role in dictating cellular interactions, human health, and pathological processes. This crucial modification is mediated by a family of twenty distinct human sialyltransferases whose exquisite substrate specificities and st...

Lucas Lancel, Sushmaa Dangudubiyyam, Clémence Simon et al. · Biology Methods and Protocol... · 0 citations

Open access Sep 2026

Species-specific disordered regions and temperature dependence of bisecting GlcNAc-synthetic enzyme MGAT3.

MGAT3 (GnT-III) is a glycosyltransferase that catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the central β-mannose in N-glycans, generating bisecting GlcNAc. These bisecting GlcNAc-bearing N-glycans are implicated in cancer and Alzheimer's disease and negatively regulate N-glycan maturation. Although the bio...

Wan-Xue Bao, Shunji Natsuka, A. Harduin-lepers et al. · Journal of Biological Chemis... · 0 citations