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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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A. Harikrishnan

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Open access Aug 2026

Evaluating the Impact of Principal Component and Mixed Model Approaches on Polygenic Risk Score Portability to Diverse Ancestries in the UK Biobank

Polygenic risk scores (PRS) offer considerable potential for precision medicine. How ever, their predictive performance often attenuates when applied to populations that differ from the genome-wide association study (GWAS) training population. There are many potential sources of this portability problem, and one relati...

A. Harikrishnan, C. M. Kelly · 0 citations

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