Open access
Oct 2026
Development of a messenger RNA therapy for schizophrenia.
BACKGROUND Few gene-disease associations identified by human genetic studies lead to new drugs that advance to first-in-human trials. Schizophrenia exemplifies this translational gap: thousands of gene-disease associations have been reported, but antipsychotics act via mechanisms introduced in the 1950s. To close the g...
N. Simons, Vibhuti Patel, Hao-Yuan Li et al.
· Biological Psychiatry · 0 citations