BACKGROUND
Oligodendroglioma is a primary central nervous system tumor classified by the presence of isocitrate dehydrogenase (IDH) mutations and codeletion of 1p/19q. A lack of faithful preclinical model systems for this disease has limited progress in understanding the biology of this genetically unique subtype of ad...
Ipsita G. Kundu, Nicolas Toro, Aaron Y. Mochizuki et al.· Neuro-Oncology· 0 citations
Cellular function depends on the spatial organization of cells and biomolecules within the tissue microenvironment. Advances in spatial omics have enabled profiling of molecular features such as transcriptome, proteome and epigenome, and there has been rapid progress of imaging-based approaches to study spatial three-d...
Ping Wang, Juan Wang, Qi-Xuan Wang et al.· Nature Methods· 0 citations
Glioblastoma, IDH-wildtype, is characterized by diffuse invasion, profound immunosuppression, treatment resistance, and near-inevitable recurrence. Although canonical genetic alterations establish malignant capacity, they do not fully explain how glioblastoma cells adapt to hypoxic, perivascular, invasive, immunosuppre...
Rafal Chojak, Jillyn Turunen, Noah B. Drewes et al.· Journal of Neuro-Oncology· 0 citations
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