Transcription factors (TFs) are key players in eukaryotic gene regulation, but the DNA binding specificity of many TFs remains unknown. Here, we assay 284 mostly uncharacterized putative human TFs using selective microfluidics-based ligand enrichment followed by sequencing (SMiLE-seq), revealing 74 new DNA binding moti...
Antoni J. Gralak, Kateřina Faltejsková, Ally W. H. Yang et al.· Nature Communications· 2 citations
It is found that induction of TPRX1, a known regulator of zygotic preimplantation, leads to chromatin opening at many of its binding sites in the dark matter genome, suggesting that the genome encodes many putative transcription factors.
Rozita Razavi, Ali Fathi, Isaac Yellan et al.· Nature Communications· 3 citations
There is ongoing debate regarding the degree to which transcription factors (TFs) independently specify genomic binding: TF binding motifs are typically short and degenerate, yielding many more binding site predictions than observed in cells. Here we present genomic high-throughput SELEX (GHT-SELEX)—a scalable method t...
A. Jolma, A. Hernandez-Corchado, A. Yang et al.· Nature Methods· 3 citations
Summary High metabolic heterogeneity and plasticity of triple-negative breast cancer (TNBC) contribute to therapy resistance, necessitating identification of therapeutic vulnerabilities. Here, we identify non-canonical functions of the extracellular matrix (ECM) remodeler, lysyl oxidase (LOX), in regulating glucose met...
O. Saatci, B. Ulukan, Metin Cetin et al.· Cell Reports Medicine· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
