Author

A. Hezel

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Sep 2026

Abstract B143: Functional screening of Arid1a-deficient pancreatic adenocarcinoma using the MAPS platform

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with limited therapeutic options. Approximately one-third of PDAC tumors harbor alterations in chromatin-remodeling genes, including loss-of-function mutations in ARID1A occurring in approximately 8% of cases. However, actionable vulnerabilities...

Wen-Jia Wang, Olivia Schmidt, S. Blick-Nitko et al. · Cancer Research · 0 citations

Open access Aug 2026

UNC5B regulates epithelial-to-mesenchymal transition through a SRC-ZEB1 signaling axis to facilitate pancreatic cancer metastasis

UNC5B is identified as a central molecular hub governing metastatic competence in PDAC by promoting EMT and invasion by promoting epithelial-to-mesenchymal transition (EMT) and invasion.

Muhammad Sadeqi Nezhad, Chris R. Harris, O. Prela et al. · Oncogene · 0 citations