A bioengineered ECM-mimetic dermal collagen-derived hydrogel co-delivering SDF-1α and bFGF promotes cellular recruitment, angiogenesis, and regenerative healing of type 2 diabetic wounds.
Diabetic wounds remain a complex clinical challenge due to impaired angiogenesis, prolonged inflammation, excessive oxidative stress, and defective extracellular matrix (ECM) remodeling. Biomaterial-based approaches that can simultaneously regulate these pathological events are highly desirable for promoting functional...