Inhibition of soluble epoxide hydrolase by steroidal metabolites from the starfish Patiria pectinifera: Integrated enzyme kinetic and computational studies.
Soluble epoxide hydrolase (sEH) is a promising therapeutic target for inflammation-related disorders; however, current synthetic inhibitors are limited due to pharmacokinetic constraints. Marine steroidal metabolites offer a potential source of natural sEH inhibitors. Therefore, this study aims to investigate the sEH i...