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Open access Aug 2026

Preoperative Inflammatory Markers and Sonographic Free Peritoneal Fluid in Relation to Histopathologically Confirmed Appendiceal Perforation in Children: A Retrospective Cohort Study

Background/Objectives: Distinguishing perforated from non-perforated appendicitis preoperatively is difficult, and routine scores diagnose appendicitis rather than grade severity. We examined whether two inflammatory markers and one sonographic sign, combined in a model, discriminate between perforated and non-perforat...

Paul Tchouala Tchakoute, Răzvan Roșca, A. Iuhas et al. · 0 citations
Open access Aug 2026

Exploratory Analysis of Factors Associated with Conversion After Initially Attempted Laparoscopic Appendectomy in Children: The Role of Inflammatory Markers and Clinical Scores

Background: Acute appendicitis is the leading pediatric surgical emergency. Identifying drivers of disease severity and laparoscopic-to-open conversion remains critical for surgical planning. We evaluated the discriminative performance of clinical scores and inflammatory biomarkers for both peritonitis and surgical con...

Paul Tchouala Tchakoute, A. Iuhas, V. Nechita et al. · 1 citation
Open access Sep 2026

Bridging the Gap in Eastern European Cystic Fibrosis Care: How Newborn Screening and Advanced CFTR Modulation Shape the Clinical Landscape in Western Romania

Cystic fibrosis characterization in western Romania demonstrates rapid modulator uptake and preserved lung function while highlighting persistent gaps in nutritional status, microbiological burden, and case detection relative to Western European populations.

C. Marinău, C. Sava, A. Iuhas et al. · 0 citations

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