Hesperidin Mitigates Skeletal Muscle Ischemia-Reperfusion Injury via Nrf2, NF-κB, and NLRP3 Pathways.
The application of tourniquets during limb surgery can lead to ischemia-reperfusion (IR) injury, a pathological process characterized by excessive oxidative stress, increased inflammatory signaling, and progressive muscle fiber damage. Hesperidin, a bioactive flavonoid derived from citrus fruits, is known for its antio...