A. J. Martín-Galiano

Mapping the Human Ghost Proteome: Classification and Experimental Detection Biases in the Identification of Alternative Microproteins

The discovery of alternative proteins (AltProts), translated from non-canonical ORFs, has expanded the human proteome and revealed a hidden layer known as the “ghost proteome”. Despite increasing evidence, AltProts detection remains challenging due to their small size, physicochemical heterogeneity, and lack of annotat...