Succinate dehydrogenase (SDHB, SDHC, SDHD) gene variants significantly modify clinical outcomes in paraganglioma-pheochromocytoma but have a limited impact on head and neck paraganglioma.
PURPOSE Succinate dehydrogenase (SDH) gene variant types differentially influence risk for thoracic-abdominal paraganglioma-pheochromocytoma (PPGL) and head and neck paraganglioma (HNPGL), but quantitative correlations are lacking. METHODS In this genotype-phenotype study of 2706 patients with PPGL-HNPGL and SDH vari...