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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

A. Jirgensons

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2 papers indexed here

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Open access Sep 2026

Targeting the AcrAB-TolC efflux pump by small molecules selectively addressing the outer membrane factor TolC

Background Gram-negative bacteria express several efflux pump complexes extruding a broad spectrum of antibiotics. The major efflux pump in E. coli is the AcrAB-TolC complex that expels a broad spectrum of antibiotics from the bacterium, resulting in impaired efficacy of these drugs. Therefore, the inhibition of efflux...

Janis Veliks, Cristina D. Cruz, Tania Szal et al. · 0 citations
Open access Aug 2026

Deconstruction of Aspartic Protease Inhibitors Enables Fragment‐Based Discovery of Plasmepsin V Inhibitors

A structure‐informed, deconstruction‐based approach is applied to identify non‐peptidomimetic PMV inhibitors by mining catalytic dyad‐binding motifs from experimentally solved aspartic protease–inhibitor complexes and assembling a focused fragment‐like library.

M. Skvorcova, Laura Ruduša, D. Zelencova-Gopejenko et al. · 0 citations

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