Aug 2026
Discovery of a novel CDK8 inhibitor as dual suppressor of NF-κB-driven inflammation and promoter of Treg differentiation for psoriasis treatment.
LW-1 represents a promising CDK8 inhibitor with improved drug-like properties and potent anti-psoriatic efficacy, providing a potential therapeutic candidate for the treatment of psoriasis and other inflammatory diseases.
Cen-Cen Lei, Dawei Jin, A-Jun Liu et al.
· Bioorganic chemistry (Print) · 0 citations