DEVELOPMENT AND OPTIMIZATION OF GUAR GUM-BASED RIFAXIMIN MICROSPHERES FOR COLON-TARGETED DRUG DELIVERY USING 32 FACTORIAL DESIGN
Objectives: The present study aimed to develop and optimize guar gum-based rifaximin microspheres for colon-targeted drug delivery using a 32 factorial design to achieve controlled drug release and improve localized delivery to the colon. Methods: Rifaximin-loaded microspheres were prepared by the emulsion solvent evap...