Open access
Sep 2026
Integrative pipeline to profile and target endocrine therapy-insensitive cell populations in ER+ breast cancer
An analytical pipeline is developed to systematically identify and target ET-insensitive cell populations within tumors by integrating single-cell RNA sequencing of ER+ tumors from the FELINE clinical trial with functional validation in a panel of patient-derived xenograft organoid models.
S. Semina, R. Huggins, Hui-Ping Zhao et al.
· bioRxiv · 0 citations