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Open access Oct 2026

Comparative neuropathological evaluation of pT217 immunoreactivity in human and transgenic mouse tauopathies.

Tau phosphorylation at threonine 217 (pT217) has been increasingly recognized as a biomarker for Alzheimer disease (AD), but its neuropathological distribution and the performance of available antibodies remain to be fully characterized. In this study, we performed a comparative evaluation of a recombinant rabbit monoc...

Emi Higashiizumi, Hiroshi Shimizu, Takaaki Nishikawa et al. · 0 citations
Open access Oct 2026

Insertion or deletion variants in TAF15 exon 15 are genetic factors impacting the prognosis of amyotrophic lateral sclerosis in a Japanese cohort.

The influence of genetic factors on the prognosis of amyotrophic lateral sclerosis (ALS) has attracted considerable attention, with numerous studies exploring this relationship in clinically diagnosed patients. The present study attempted to clarify the precise impact of genetic factors on prognosis in patients with pa...

Yuya Hatano, Tomohiko Ishihara, M. Tada et al. · 0 citations

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