Forkhead box (FOX) proteins are transcription factors whose dysregulation drives tumor initiation, metastasis, and therapy resistance, yet their direction of effect is determined by cellular context rather than by their conserved DNA-binding domain. Applying explicit criteria across all 44 human members, we find contex...
Sara Alrawashdeh, Gazia Buzaakuk, Raghd Obidat et al.· Drug Discovery Today· 0 citations
Gaining deeper mechanistic insight into the nature of HyT degradation will be essential to further the potential of HyTDs as powerful tools in cancer research and therapeutics.