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Author

A. Karunathilaka

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2 papers indexed here

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Review Open access Sep 2026

Emerging NPR-B agonists for cartilage and bone: from CNP biology to translational compound design

Disorders affecting cartilage and bone development frequently originate from disrupted endochondral ossification within growth-plate cartilage. Nonetheless, few therapeutic interventions directly target the local signaling pathways governing this process. This review explores the C-type natriuretic peptide (CNP)/natr...

Yasuhiko Ago, A. Karunathilaka, Jacky M. Guerrero-Vargas et al. · 0 citations
Open access Aug 2026

Comprehensive characterization and translational implications of the GalnsR384C mouse model of Mucopolysaccharidosis IVA.

Mucopolysaccharidosis IVA (MPS IVA) is a lysosomal storage disorder caused by a deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), leading to progressive accumulation of keratan sulfate (KS) and chondroitin-6-sulfate (C6S) and resulting in systemic skeletal dysplasia. Severe, early-onset disease is freque...

Dione A Holder, B. Çelik, Sampurna Saikia et al. · 0 citations

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