A. Kaye

Neuroimmune Interactions in Chronic Pain and Neuroinflammation: Peripheral Nerve Injury, Neuroimmune Mechanisms, and Therapeutic Recovery

The pathogenesis of chronic pain includes persistent neuroimmune interactions that contribute to both peripheral and central pain sensitization. Tissue injury and peripheral nerve injury activate immune and glial pathways through various cytokines, chemokines, complement, damage-associated molecular patterns (DAMPs), a...

Selective EP4 Receptor Antagonism for Osteoarthritis Pain: Emerging Evidence and Future Directions for KF-0210.

Osteoarthritis (OA) is a leading cause of chronic pain and disability. Its increasing global prevalence and substantial socioeconomic burden highlights need for safer and more effective therapeutic strategies. Current pharmacological treatments provide symptomatic relief; however, are limited by gastrointestinal, cardi...

Erector Spinae Plane Block vs. Intercostal Nerve Block for Pain Management in Thoracic Surgeries and Chest Wall Traumas: A Meta-Analysis

Mechanobiology of Exosome-Mediated Regeneration: Mechanisms, Translational Advances, and Future Therapeutic Directions

Chronic musculoskeletal pain remains a leading cause of disability worldwide, driven by progressive degeneration of cartilage, bone, tendon, intervertebral discs, and peripheral nerves. Conventional interventional approaches primarily address symptoms without restoring structural integrity or tissue homeostasis. Regene...

Common Pain Medications: Indications, Efficacy, Dosing, Formulations, Mechanisms of Action, and Contraindications.

Pain pharmacology encompasses a complex relationship between neurobiological pathways, receptor systems, and pharmacologic agents that mediate or modulate pain perception and inflammation. In the context of the ongoing opioid crisis, understanding traditional and emerging approaches to pain management is critical. This...

The Evolving Role of Peripheral Nerve Stimulation in Postoperative Analgesia and Recovery

Pridopidine Mediated Sigma-1 Receptor Activation and Therapeutic Implications in Neurodegenerative Diseases

Neurodegenerative diseases are targets for pridopidine therapy, which aims to improve quality of life through neuroprotective mechanisms that involve sigma-1 receptor (S1R) activation. Neurodegenerative motor and cognitive diseases are influenced by dopamine imbalance, where disruptions in pathways contribute to states...

State of the Art in Neuromodulation or Spinal Cord Stimulation Therapy

Future progress in SCS will likely depend on artificial intelligence, remote monitoring, biomarker-guided programming, and integration with multidisciplinary chronic pain care.