Author

A. Khan

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Open access Oct 2026

Integrated Transcriptomic and Regulatory Network Analysis Reveals Distinct Molecular Subtypes with Prognostic Significance in Clear Cell Renal Cell Carcinoma

Background: Clear cell renal cell carcinoma (ccRCC) shows molecular heterogeneity that complicates prognosis and selection of therapy. Integration of upstream pathway activity and transcription factor (TF) regulatory networks with gene expression to define molecular subtypes remains underexplored. Methods: We harmonize...

M. A. Zahid, W. Kouidri, A. Khan et al. · Cancers · 0 citations

Oct 2026

Regioselective copper-catalyzed domino synthesis of 7-iodobenzo[d]oxazoles as potential ERβ ligands.

7-Halogenated benzoxazoles are a recurring motif in preclinical ligands for the estrogen receptor β (ERβ) and in other oxazole-based pharmacophores, yet selective and direct access to the 7-halo regiochemistry is not well served by classical condensation routes or by existing copper-catalyzed arylation methods. Here we...

W. K. Al-Jammal, Raed M. Al-Zoubi, Sally R. Al-Zoubi et al. · Organic and biomolecular che... · 0 citations

Oct 2026

Integrated expression profiling and structure-based drug discovery identify EGFR as a druggable target and Tripterygium wilfordii phytochemicals as potential therapeutics for autosomal dominant polycystic kidney disease.

Autosomal dominant polycystic kidney disease (ADPKD) is a progressive genetic disorder characterized by renal cyst formation and eventual kidney failure, with limited effective therapeutic options. In this study, we employed an integrated computational framework combining microarray-based gene expression profiling, net...

I. U. Haq, Israr Hussain, A. Mohammad et al. · Computational biology and ch... · 0 citations