Author

A. Kobro‐Flatmoen

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Open access Aug 2026

Mechanisms of resilience to autosomal dominant Alzheimer’s disease via oligogenic modulation of rare variants in the entorhinal cortex

Two PSEN1 E280A carriers have presented extreme protection against autosomal dominant Alzheimer’s disease (ADAD), with over two decades of delay for dementia onset. One of them, a male heterozygous for the RELN-COLBOS protective variant showed increased neuronal density in the entorhinal cortex 1. We conducted a deep p...

Yassir El-Amri, N. Villalba-Moreno, Julia A. Urban et al. · bioRxiv · 0 citations

Open access Aug 2026

High reelin expression may explain why a subgroup of entorhinal cortex neurons functions as an initial nucleation site of Alzheimer’s disease

It is shown that, in a senescent physiology predisposing to frequent inflammation-driven Aβ42 production bursts over a decades-long period, the intracellular amount of Aβ42-reelin complexes can accumulate to extraordinarily high levels in anterolaterally positioned LII neurons compared to the vast majority of cortical...

A. Kobro‐Flatmoen, J. Hussan, P. Hunter et al. · PLoS Computational Biology · 0 citations