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A. L. Burlingame

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Open access Oct 2026

Optimization of Search and Acquisition Strategies for DSSO Crosslinking Mass Spectrometry using Protein Prospector and Touchstone

Crosslinking mass spectrometry (XL-MS) enables residue-level characterization of protein-protein interactions (PPIs) in both purified assemblies and complex biological systems. Cleavable crosslinkers such as DSSO are widely used to facilitate analysis of complex samples, yet there remains limited consensus on how best...

M. Trnka, Clinton Yu, Peter R. Baker et al. · 0 citations
Open access Jul 2026

α2δ-1 regulates synaptic AMPA receptor trafficking and LTP through distinct pre- and postsynaptic functions.

This work identifies α2δ-1 as an extracellular AMPAR regulatory protein with distinct pre- and postsynaptic functions: in cis, limiting AMPAR access to synapses; in trans, facilitating LTP.

Gerardo Leana-Sandoval, Matthew A. Sandoval, Ananth V. Kolli et al. · 0 citations

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