Open access
Oct 2026
Progressive remodeling of global protein interaction networks in a mouse model of tauopathy.
Neurodegenerative disease is marked not just by loss of proteins or cells, but by dynamic rewiring of macromolecular interaction networks that precede and drive pathology. Here, we present a temporally resolved, systems-scale map of multi-protein complex remodeling in a tauopathy model, integrating co-fractionation mas...
Wei-Wei Lin, S. Phanse, S. V. D. van der Spek et al.
· Cell Reports · 0 citations