Open access
Sep 2026
CD38 inhibition preserves adult human hematopoietic stem cells
In humans, long-term hematopoietic stem cells (LT-HSCs) are enriched within the CD34⁺CD38 low fraction in vivo, and CD38 abundance typically rises with lineage commitment, suggesting that CD38 may function as a negative regulator of stem cell function. Here, we show that pharmacologic CD38 inhibition with 78c dur...
Jian-Yi Ding, Daisuke Araki, Yong-Qin Li et al.
· Cell Death & Disease · 0 citations