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Review Open access Oct 2026

Caspase-1 and Inflammasome Signaling in Spinal Cord Injury: Mechanistic Insights and Translational Gaps

Caspase-1 is a central mediator of canonical inflammasome signaling and drives neuroinflammatory injury through interleukin-1β (IL-1β) and interleukin-18 (IL-18) maturation, gasdermin D (GSDMD)-mediated pyroptosis, and secondary inflammatory cascades. In spinal cord injury (SCI) and other neurologic disorders, experime...

Adonicah Y. Cummings, Adham M. Khalafallah, Bhavjeet S. Sanghera et al. · 0 citations
Case report Open access Aug 2026

Endoscopic transforaminal discectomy for far lateral disc herniation at L3–L4: A 2-dimensional operative video

Background: Far lateral disc herniations (FLDHs) comprise approximately 7–12% of all lumbar disc herniations and involve protrusion of disc material within or lateral to the intervertebral foramen. Compression of the exiting nerve root and dorsal root ganglion at the same intervertebral level may result in more severe,...

Anshul Ratnaparkhi, A. Levy, K. Shah et al. · 0 citations

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