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Author

A. Livada

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Sep 2026

Platelet peptidylarginine deiminase 4 is not essential for platelet function in homeostasis or fibrosis during normal aging.

BACKGROUND AND OBJECTIVES Fibrotic remodeling is a key feature of cardiac aging and a major contributor to heart failure. The bidirectional interplay between platelets and neutrophil extracellular traps (NETs), with peptidylarginine deiminase 4 (PAD4) facilitating NET formation, has emerged as a mediator of fibrotic re...

K. Bomhals, Sirima Kraisin, V. Spalart et al. · 0 citations

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