Author

A. Lucius

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Open access Sep 2026

TFIIS enhancement of Pol II cleavage is under kinetic control

Abstract The eukaryotic RNA polymerases (Pols) contain subunits or interact with trans-acting factors that confer robust endonuclease activity. A12.2 and C11 are subunits of Pol I and Pol III, respectively. Pol II, however, recruits transcription factor IIS (TFIIS). This evolutionary divergence of A12.2 and C11 being b...

Ryan M. Requijo, N. K. Maluf, D. Schneider et al. · Nucleic Acids Research · 0 citations

Open access Aug 2026

Biased stochastic motor dynamics drive bidirectional, processive translocation by the AAA+ disaggregase Hsp104

Protein aggregation disrupts proteostasis and drives neurodegeneration. Hsp104 is a hexameric, ring-shaped AAA+ ATPase that dissolves protein aggregates, yet how hexamers translocate and extract polypeptides trapped in mechanically resistant aggregates remains unclear. Using substrates that recapitulate the physical co...

Jia-Bei Lin, Jaskamaljot Kaur Banwait, A. Saurabh et al. · bioRxiv · 0 citations