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Open access Aug 2026

Prefrontal-raphe-habenular circuit drives fear memory recall and updating

Fear memory recall is a vital defensive response, yet its underlying neuronal mechanism remains incompletely understood. Here, we identify an effective fear recall pathway. We found that hippocampal and amygdalar memory centers directly target a group of medial prefrontal cortex (mPFC) neurons, which are necessary for...

Boldizsár Zsolt Balog, Albert M Barth, Krisztián Zichó et al. · 0 citations
Open access Aug 2026

Deleting learning-induced dendritic spines disrupts the memory they encode

Long-term memory is widely thought to depend on activity-dependent synaptic plasticity and the structural remodeling that accompanies it, yet direct causal evidence that this remodeling is required for memory storage has been lacking. A case in point is the formation of dendritic spines: new spines appear following lea...

Hiranmay Joag, Patricio Opazo, Kenta M. Hagihara et al. · 0 citations

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