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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

A. M. Pasmooij

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Review Open access Sep 2026

Clinical and regulatory acceptability of hierarchical composite endpoints in infectious disease clinical trials.

OBJECTIVES Hierarchical composite endpoints (HCEs) combine different clinical attributes in a single endpoint and establish a ranking of these components based on clinical importance. We studied the acceptance of HCEs in infectious disease clinical trials for clinical and regulatory decision-making. METHODS We conduc...

A. de Jong, Daphne S. A. Bennink, Selina Ehrenzeller et al. · 0 citations

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