Author

A. M. Schwartz

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Open access Aug 2026

SLE-Associated rs2295613(A) Allele Strengthens a Predicted c-MYC Motif and Enhances SLAMF1 Promoter Reporter Activity in B Cells

Highlights What are the main findings? rs2295613(A) increased SLAMF1 promoter reporter activity in Raji, MP1, and primary CD19+ B cells. Motif disruption and partial MYC depletion reduced the activity of the rs2295613(A)-containing reporter. What are the implications of the main findings? The regulatory activity associ...

A. Uvarova, Lidia V. Putlyaeva, Kirill V. Korneev et al. · Cells · 0 citations

Open access Aug 2026

Promoter identity shapes splicing outcomes and fidelity

It is found that promoter identity, rather than expression level, exerts strong and highly context-specific effects on cassette exon inclusion, exceeding the effect of pharmacological inhibitors of transcription initiation or elongation.

S. Shanas, A. M. Schwartz, Noa Nesher et al. · Nature Communications · 0 citations