Author

A. M. Silber

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Open access Oct 2026

Anti-trypanosomal activity and target validation of the M17 leucyl-aminopeptidase inhibitor DDD00057570 in Trypanosoma cruzi

Background Chagas disease, caused by the parasite Trypanosoma cruzi, affects six to seven million people, and its treatment still relies on two drugs introduced more than fifty years ago, both of limited efficacy and poorly tolerated. The major acidic M17 leucyl-aminopeptidase of T. cruzi is expressed in all developmen...

M. Aguado, Janaina de Freitas Nascimento, M. B. Alencar et al. · bioRxiv · 0 citations

Review Open access Aug 2026

Metabolomic profiling for the identification of drug targets in trypanosomes

Trypanosomes belong to a group of unicellular flagellated eukaryotes which include species responsible for serious, potentially fatal human diseases, mainly occurring in tropical and subtropical regions of the world: Trypanosoma brucei for sleeping sickness in Africa, Trypanosoma cruzi for Chagas disease in the A...

Maura Rojas-Pirela, Diego Andrade-Alviárez, W. Quiñones et al. · Frontiers in Chemical Biolog... · 0 citations