Review
Open access
Sep 2026
The mitochondrial theory of sleep: an integrative framework for understanding sleep-wake regulation
Sleep is an essential biological function with unclear mechanisms. Recent research links the circadian clock, energy metabolism, calcium handling, reactive oxygen species (ROS) production, and synaptic plasticity to cognitive performance. Given that mitochondria regulate cellular energy production, calcium buffering, a...
Seithikurippu R. Pandi-Perumal, Sayan Paul, K. Saravanan et al.
· Frontiers in Psychiatry · 0 citations