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Open access Aug 2026

Tolerability, dose modification, and treatment compliance with adjuvant abemaciclib in high-risk early breast cancer: a UK real-world multicentre study (CONCISE)

Background Abemaciclib plus endocrine therapy improves outcomes in high-risk hormone receptor-positive, HER2-negative early breast cancer (EBC) in monarchE, but real-world tolerability, dose modification, and treatment persistence in routine UK practice remain incompletely characterised. Patients and methods A retrospe...

H. Abdallah, Y. Owoseni, B. Baraka et al. · 0 citations
Review Open access Aug 2026

IUC26658-92 Efficacy Patterns of First-Line Immune Checkpoint Inhibitor Combinations in Metastatic Clear Cell Renal Cell Carcinoma: A Systematic Review and Meta-Analysis Evaluating Ethnic Variations

An ethnicity-based benchmarking analysis of therapeutic outcomes across standard-of-care ICI combination regimens demonstrates consistent clinical efficacy across Asian and Caucasian populations, with no statistically significant or clinically meaningful divergence in ORR or PFS.

D. Khanna, T. Dey, E. Blanchard-Cavagis et al. · 0 citations

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