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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

A. Mantoulidis

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Jul 2026

Abstract IA06: Title of the talk: KRAS - Degrading the Undruggable

This work developed panKRAS degraders using a structure-guided strategy combining reversible KRAS binders with VHL-recruiting PROTACs and enables potent pan-allelic degradation, including ON-biased mutants, establishing KRAS degradation as a viable therapeutic modality and positioning ACBI4 as a pioneering panKRAS ON/OFF chemical probe.

A. Mantoulidis · 0 citations