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Author

A. Markou

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Open access Dec 2010

Repeated administration of the GABAB receptor positive modulator BHF177 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine seeking in rats

Results showed that BHF177 selectively blocked nicotine self-administration and prevented cue-induced reinstatement of nicotine seeking, with minimal effects on responding for food and no effect on cue-induced reinstatement of food seeking, which could be useful therapeutics for the treatment of different aspects of nicotine dependence.

S. Vlachou, S. Guéry, Wolfgang Froestl et al. · 770 citations · ⚡47