Author

A. Maršavelski

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Open access Jul 2026

Behind substrate specificity switch in lactate dehydrogenase: Active-site loop dynamics and epistatic enhancement.

These findings support an electrostatic-steric ensemble-selection model for LDH/MDH specificity and provide a mechanistic framework for engineering substrate specificity in Rossmann-fold dehydrogenases.

Hanfeng Cai, S. Shulami, T. Hrenar et al. · International Journal of Bio... · 0 citations