Review
Open access
Oct 2026
The insulin gene in humans and mice: evolution, regulation, and sex-specific mechanisms of diabetes susceptibility
The insulin gene (INS) encodes a peptide hormone critical for glucose homeostasis, and its dysregulation underlies both type 1 and type 2 diabetes mellitus. This review compares the structural organization and functional regulation of the insulin gene in humans and mice, highlighting key species differences including t...
A. Mazloum, N. Batashkov, Veronika S. Ledyaeva et al.
· Frontiers in Endocrinology · 0 citations