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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

A. McLysaght

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Open access Aug 2026

A Duplicate Resolved Paddlefish Genome Provides Insights into the Mechanisms of Rediploidisation and Hox Cluster Evolution

Whole-genome duplication (WGD; or polyploidy) has played a major role in the evolution of many lineages however, our understanding of the processes that shape genome evolution following WGD remains incomplete. While polyploidy duplicates the entire genome sequence, it is rediploidisation that establishes independent du...

Dearbhaile Casey, Lukasz Niezabitowski, M. K. Gundappa et al. · 0 citations
Open access Aug 2026

A comprehensive and accessible database of jawed-vertebrate ohnologs

Whole-genome duplications (WGDs) profoundly shaped early vertebrate evolution. The set of paralogs retained from these events—“ohnologs”—has had lasting impacts on genome structure and function, including disease gene enrichment. Despite this, we still lack a gold standard ohnolog database. Here, we have harnessed ance...

Łukasz Niezabitowski, Róisín Long, Anthony K. Redmond et al. · 0 citations
Open access Aug 2026

An automated pipeline for reconstructing whole genome duplications

This work develops an automated and user-friendly pipeline for reconstructing ancestral chromosomes before and after WGD, and uses the conservation of gene content to infer chromosomal rearrangement events in this timeframe.

Łukasz Niezabitowski, Anthony K. Redmond, A. McLysaght · 0 citations

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