Author

A. Melk

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Open access Sep 2026

Insights Into the Interplay Between the Senescent Cells and Immune Cells

Aging kidneys exhibit accumulation of senescent cells together with sterile low‐grade inflammation. However, the spatial organization of senescence‐associated immune cell accumulation in the aging kidney remains poorly defined. We systematically analyzed kidneys from young, middle‐aged, and aged mice, focusing on the s...

Martin Jaros, Marco Schmidt, L. Neubert et al. · Aging Cell · 0 citations

Open access Jul 2026

Treatment response to daratumumab in antibody-mediated kidney allograft rejection: evidence from serial protocol biopsies

ABSTRACT Background Antibody-mediated rejection (ABMR) is a major cause of chronic allograft dysfunction and graft loss after kidney transplantation (KTx). Daratumumab, antibody targeting the transmembrane glycoprotein CD38 (cluster of differentiation) on immune cells, has shown promise in the treatment of refractory A...

N. Kanzelmeyer, M. Verboom, M. Hallensleben et al. · Clinical Kidney Journal · 0 citations

Aug 2026

Comparative Effectiveness of Combination Therapy in Patients with Chronic Kidney Disease and Diabetes mellitus Type 2 using Real World Data.

BACKGROUND AND HYPOTHESIS Diabetes mellitus type 2 (T2DM) is the primary driver of chronic kidney disease (CKD). Renin-angiotensin-aldosterone system inhibitors (RAASi) represent basic therapy for CKD in T2DM. Recent studies demonstrated renal benefits of sodium glucose cotransporter 2 inhibitors (SGLT-2i) and glucagon...

J. Casper, Julian Doricic, Zhe-Jia Tian et al. · Nephrology, Dialysis and Tra... · 0 citations