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Open access Sep 2026

Tuning intracellular immunity by Nodamura virus B2 protein enhances self-amplifying RNA activity

Self-amplifying RNA (saRNA) offers a powerful approach for vaccine development, as its replicative nature within cells provides prolonged antigen expression together with self-adjuvanticity. However, its potency is often limited by innate immune responses, particularly those triggered by intracellular double-stranded R...

R. Y. Sanchez-David, Josephine Nemegeer, Hoang Duy Le et al. · 0 citations
Open access Aug 2026

Pyridin-3-carbohydrazide strongly impairs Mayaro and Chikungunya virus replication in vitro

Alphaviruses, including Mayaro virus (MAYV) and Chikungunya virus (CHIKV), pose a growing public health threat, with increasing reports worldwide and no licensed antiviral treatments available. This study evaluated the antiviral activity of pyridine-3-carbohydrazide (P-3-C) against MAYV (strains BeAr and TRVL) and CHIK...

N. Contreras, N. Cassani, Mikaela dos Santos Marinho et al. · 0 citations

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